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TrizEDTA®

By itself, tris-EDTA (tris-ethylene diamine tetra-acetic acid) is bacteriostatic, but when used in combination with an antibiotic, it becomes bacteriocidal, decreasing the minimum inhibitory concentration of even multidrug-resistant antibiotics. It works by damaging the outer wall of bacteria, making the organisms more permeable, and has a synergistic effect with antibiotics and other agents like chlorhexidine.3,6 Tris-EDTA is also an antibiofilm agent and may help overcome resistance induced by upregulation of Pseudomonas spp. efflux pumps.3,5

  • Cleaning/flushing the ear removes debris, purulent material or secondary infections in the external ear canal.
  • Consider flushing the ear canal under general anesthesia in hospital if the pet owner is not able to clean the ears at home as some topical antimicrobials, such as aminoglycosides, are inactivated by purulent material.
  • Cleaning with TrizEDTA should occur 15 to 30 minutes before applying topical antimicrobials and does not appear to be ototoxic.

Figure. Graphic illustration of Dechra TrizEDTA technology. Tris-EDTA helps to perforate the cell wall. This action on the pathogen potentiates antimicrobial killing power.3,6

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